Dorsolateral Prefrontal Cortex, Working Memory, and Prospective Coding for Action

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Dorsolateral prefrontal cortex, working memory, and prospective coding for action.

Rogier B. Mars1,2 and Meike J. Grol3,4 1Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology and 2Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, United Kingdom, 3Helmholtz Research Institute, Experimental Psychology, Utrecht University, 3584 CS Utrecht, The Netherlands, and 4F.C. Donders Centre for Cognitive Neuroimaging, Radbo...

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Dorsolateral prefrontal contributions to human working memory.

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Dorsolateral prefrontal cortex promotes long-term memory formation through its role in working memory organization.

Results from neuroimaging studies have shown that the dorsolateral prefrontal cortex (DLPFC) implements processes critical for organizing items in working memory (WM). Based on its role in WM, we hypothesized that the DLPFC should contribute to long-term memory (LTM) formation by strengthening associations among items that are organized in WM. We conducted an event-related functional magnetic r...

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Human Dorsolateral Prefrontal Cortex Is Not Necessary for Spatial Working Memory.

A dominant theory, based on electrophysiological and lesion evidence from nonhuman primate studies, posits that the dorsolateral prefrontal cortex (dlPFC) stores and maintains working memory (WM) representations. Yet, neuroimaging studies have consistently failed to translate these results to humans; these studies normally find that neural activity persists in the human precentral sulcus (PCS) ...

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ژورنال

عنوان ژورنال: Journal of Neuroscience

سال: 2007

ISSN: 0270-6474,1529-2401

DOI: 10.1523/jneurosci.5344-06.2007